Nutritional supplements and methods for making and using such supplements are described. In particular, this application describes nutritional supplements with a first part containing an effective amount of a lipoic acid (such as ALA) and a second part containing an effective amount of a sulfur containing compound that increases the level of cellular glutathione (such as NAC). The first and second parts are kept partially or completely separated from each other, thereby minimizing their reaction and maximizing their effectiveness. Such nutritional supplements can be administered to mammals to increase the levels of glutathione while maintaining or increasing the stability of these two components while they are contained in the supplement. Other embodiments are described.
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